Bupivacaine HCl (HSDB 7790)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$145	Check With Us
5g	$400	Check With Us
10g	$600	Check With Us

: [email protected] [email protected]

Cat #: V1642 CAS #: 18010-40-7 Purity ≥ 98%

Description: Bupivacaine HCl (AH250; HSDB7790; SKY0402; AH-250; Win-11318; HSDB-7790; SKY-0402; Marcaine), the hydrochloride salt of Bupivacaine, is a potent inhibitor of cAMP production that also binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells.

References: Casati A, et, al. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 2005 Jun;19(2):247-68.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	324.89
Molecular Formula	C18H28N2O.HCl
CAS No.	18010-40-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 65 mg/mL (200.1 mM)r
	Water: 23 mg/mL (70.8 mM)r
	Ethanol: 65 mg/mL (200.1 mM)
Synonyms	Marcaine; AH-250; Win-11318; HSDB7790; SKY0402; AH 250; Win 11318; AH250; HSDB 7790; SKY 0402; HSDB-7790; SKY-0402; Win11318

Protocol	In Vitro	Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0780 mL	15.3898 mL	30.7796 mL	61.5593 mL
5mM	0.6156 mL	3.0780 mL	6.1559 mL	12.3119 mL
10mM	0.3078 mL	1.5390 mL	3.0780 mL	6.1559 mL
20mM	0.1539 mL	0.7695 mL	1.5390 mL	3.0780 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.