BTC (Estrogen receptor modulator 1)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1850 | Check With Us |
| 500mg | $2750 | Check With Us |
| 1g | $4125 | Check With Us |
: Cat #: V17164 CAS #: 63676-22-2 Purity ≥ 99%
Description: BTC, formerly known as RALOXIFENE CORE, is a selective and orally active estrogen receptor modulator (SERM) with a pIC50 of 0.46.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 242.29 |
|---|---|
| Molecular Formula | C14H10O2S |
| CAS No. | 63676-22-2 |
| Synonyms | BTC |
| Protocol | In Vitro | Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days |
|---|---|---|
| In Vivo | Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors | |
| Animal model | 4-6 week old athymic mice (Harlan-Sprague-Dawley) | |
| Dosages | 1.5 mg/animal | |
| Administration | p.o. ; daily for 2 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.1273 mL | 20.6364 mL | 41.2729 mL | 82.5457 mL |
| 5mM | 0.8255 mL | 4.1273 mL | 8.2546 mL | 16.5091 mL |
| 10mM | 0.4127 mL | 2.0636 mL | 4.1273 mL | 8.2546 mL |
| 20mM | 0.2064 mL | 1.0318 mL | 2.0636 mL | 4.1273 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.