BSJ-4-116
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1950 | Check With Us |
| 500mg | $3250 | Check With Us |
| 1g | $4875 | Check With Us |
: Cat #: V2485 CAS #: 2519823-34-6 Purity ≥ 99%
Description: BSJ-4-116 is a novel, potent and selective CDK12 degrader (PROTAC)( IC50 = 6 nM).
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| Molecular Weight (MW) | 837.38 |
|---|---|
| Molecular Formula | C40H49ClN8O8S |
| CAS No. | 2519823-34-6 |
| SMILES Code | O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O |
| Synonyms | BSJ-4-116; BSJ4-116; BSJ 4-116; BSJ-4116; BSJ4116; BSJ 4116; |
| Protocol | In Vitro | BSJ-4-116 regulates DDR genes via poly(adenylation). BSJ-4-116 overcomes CDK12C1039F mutation. BSJ-4-116 represents the first example of resistance to a bivalent degrader molecule that is a consequence of an acquired point mutation in the target protein. BSJ-4-116 inhibits the growth of T-ALL cells (Jurkat and MOLT-4 cells) and sensitizes them to PARP inhibition. BSJ-4-116 (50 nM; 6-24 hours) decreases the level of CDK12 protein, regardless of the mutational status of the cell line. BSJ-4-116 (10-10000 nM; 72 hours) exhibits potent antiproliferative effects in Kelly CDK12C1039F. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1942 mL | 5.9710 mL | 11.9420 mL | 23.8840 mL |
| 5mM | 0.2388 mL | 1.1942 mL | 2.3884 mL | 4.7768 mL |
| 10mM | 0.1194 mL | 0.5971 mL | 1.1942 mL | 2.3884 mL |
| 20mM | 0.0597 mL | 0.2986 mL | 0.5971 mL | 1.1942 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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%ddH2O
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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