Bromfenac Sodium (AHR 10282R)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$550	Check With Us
10g	$850	Check With Us
20g	$1280	Check With Us

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Cat #: V1048 CAS #: 91714-93-1 Purity ≥ 98%

Description: Bromfenac Sodium (formerly AHR-10282R; AHR10282R; AHR-10282, AHR10282; trade names Prolensa, Bromday, Xibrom), an approved nonsteroidal anti-inflammatory drug (NSAID), is an orally bioavailable COX-1/2 inhibitor with anti-inflammatory activity.

References: Xiaobo Zhang, et al. Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification. Bioact Mater. 2021 Jul 23;9:343-357.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	356.15
Molecular Formula	C15H11BrNO3.Na
CAS No.	91714-93-1
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 71 mg/mL (199.4 mM)rr
	Water: 71 mg/mL (199.4 mM)rr
	Ethanol: 2 mg/mL (5.6 mM)
SMILES Code	O=C(O)CC1=CC=CC(C(C2=CC=C(Br)C=C2)=O)=C1N
Synonyms	AHR 10282R; Bromfenac sodium, Prolensa, AHR-10282R; AHR10282R; Bromday, Xibrom, AHR-10282, AHR10282, AHR 10282

Protocol	In Vitro	Bromfenac (0-80 μg/mL; 24 h) can inhibit transforming growth factor-β2-induced epithelial-mesenchymal transition in HLEC-B3 in a concentration-dependent manner
	Animal model	Male Sprague-Dawley rats (150-250 g) are injected carrageenan
	Dosages	0.0032, 0.01, 0.032, 0.1, 0.32, 1.0, 3.16% (100 or 200 μL)
	Administration	Rubbed onto the backs before 1-72 h of injected carrageenan

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8078 mL	14.0390 mL	28.0781 mL	56.1561 mL
5mM	0.5616 mL	2.8078 mL	5.6156 mL	11.2312 mL
10mM	0.2808 mL	1.4039 mL	2.8078 mL	5.6156 mL
20mM	0.1404 mL	0.7020 mL	1.4039 mL	2.8078 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.