Branaplam (LMI070) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | To Be Confirmed |
| 500mg | $1480 | To Be Confirmed |
| 1g | $2220 | To Be Confirmed |
: Cat #: V3853 CAS #: 1562338-39-9 Purity ≥ 98%
Description: Branaplam HCl (LMI-070 HCl; NVS-SM1) is a potent, orally bioactive, small-molecule enhancer of SMN2 (survival of motor neuron-2) splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 429.94 |
|---|---|
| Molecular Formula | C22H28ClN5O2 |
| CAS No. | 1562338-39-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 6 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | OC1=CC(C2=CNN=C2)=CC=C1C3=NN=C(OC4CC(C)(C)NC(C)(C)C4)C=C3.[H]Cl |
| Synonyms | LMI070 HCl; NVS SM1 hydrochloride; LMI 070; NVS-SM1 HCl; LMI-070; NVSSM1 hydrochloride; |
| Protocol | In Vitro | Branaplam (LMI070; NVS-SM1) hydrochloride treatment induces changes in the levels of 175 genes in human fibroblasts |
|---|---|---|
| In Vivo | Branaplam (LMI070; NVS-SM1; 3, 10, 30 mg/kg; oral) hydrochloride produces dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3259 mL | 11.6295 mL | 23.2591 mL | 46.5181 mL |
| 5mM | 0.4652 mL | 2.3259 mL | 4.6518 mL | 9.3036 mL |
| 10mM | 0.2326 mL | 1.1630 mL | 2.3259 mL | 4.6518 mL |
| 20mM | 0.1163 mL | 0.5815 mL | 1.1630 mL | 2.3259 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.