BMS-687453
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $920 | Check With Us |
| 250mg | $1600 | Check With Us |
| 500mg | $2400 | Check With Us |
: Cat #: V2840 CAS #: 1000998-59-3 Purity ≥ 98%
Description: BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.
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| Molecular Weight (MW) | 444.86 |
|---|---|
| Molecular Formula | C₂₂H₂₁ClN₂O₆ |
| CAS No. | 1000998-59-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 31 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=C(O)CN(CC1=CC=CC(OCC2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)=C1)C(OC)=O |
| Synonyms | BMS-687453; BMS 687453; BMS687453 |
| Protocol | In Vitro | BMS-687453 is a potent and selective PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and ∼410-fold and more than 57-fold selectivity vs human PPARγ of 4100 nM and >15000 nM in PPAR-GAL4 transactivation assays. BMS-687453 exhibits high PPARα potency (EC50 = 47 nM) with ∼50-fold selectivity vs PPARγ (EC50 = 2400 nM) in HepG2 cells. However, BMS-687453 shows less potent activities in rodent PPARα functional assays, with a moderate EC50 of 426 nM for mouse and 488 nM for hamster but remains a full PPARα agonist in both species. |
|---|---|---|
| In Vivo | BMS-687453 (10, 50, 100, p.o.) dose-dependently increases serum ApoA1 protein levels and low-density lipoprotein-cholesterol (LDLc) levels in mice. BMS-687453 (1, 3, 10 mg/kg, p.o.) decreases HDLc levels in high fat-fed hamsters. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2479 mL | 11.2395 mL | 22.4790 mL | 44.9580 mL |
| 5mM | 0.4496 mL | 2.2479 mL | 4.4958 mL | 8.9916 mL |
| 10mM | 0.2248 mL | 1.1239 mL | 2.2479 mL | 4.4958 mL |
| 20mM | 0.1124 mL | 0.5620 mL | 1.1239 mL | 2.2479 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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