BMS-654457
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $6750 | To Be Confirmed |
| 200mg | $10125 | To Be Confirmed |
| 500mg | $17085 | To Be Confirmed |
: Cat #: V3489 CAS #: 1004551-41-0 Purity ≥ 98%
Description: BMS-654457 is a novel, potent, reversible small-molecule inhibitor of factor XIa (FXIa), which binds to human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.
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| Molecular Weight (MW) | 603.71 |
|---|---|
| Molecular Formula | C₃₆H₃₇N₅O₄ |
| CAS No. | 1004551-41-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)C1=CC(C(N)=O)=CC=C1C2=CC(NC(CC(C)C)=O)=CC([C@H]3NC4=C(C=C(C(N)=N)C=C4)[C@](C5=CC=CC=C5)(C)C3)=C2 |
| Synonyms | BMS-654457; BMS654457; BMS 654457; |
| Protocol | In Vitro | BMS-654457 shows comparable in vitro potency against FXIa in humans (Ki=0.2 nM) and in rabbits (Ki =0.42 nM), and was over 500-fold selective against coagulation-related proteases (thrombin, FXa and FVIIa) in these species. |
|---|---|---|
| In Vivo | BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time. BMS-654457 is a promising antithrombotic therapy with a wide therapeutic window. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6564 mL | 8.2821 mL | 16.5642 mL | 33.1285 mL |
| 5mM | 0.3313 mL | 1.6564 mL | 3.3128 mL | 6.6257 mL |
| 10mM | 0.1656 mL | 0.8282 mL | 1.6564 mL | 3.3128 mL |
| 20mM | 0.0828 mL | 0.4141 mL | 0.8282 mL | 1.6564 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Number of animals
Step Two: Enter the in vivo formulation
%DMSO
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%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.