BMS-582949 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1850 | To Be Confirmed |
| 500mg | $2650 | To Be Confirmed |
| 1g | $3975 | To Be Confirmed |
: Cat #: V2668 CAS #: 912806-16-7 Purity ≥ 98%
Description: BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 442.94 |
|---|---|
| Molecular Formula | C₂₂H₂₇ClN₆O₂ |
| CAS No. | 912806-16-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 35 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(C1=CN2N=CN=C(NC3=CC(C(NC4CC4)=O)=CC=C3C)C2=C1C)NCCC.[H]Cl |
| Synonyms | PS540446 HCl; BMS-582949; BMS 582949; BMS582949; PS-540446; PS 540446; PS540446 |
| Protocol | In Vitro | BMS-582949 is a weak inhibitor of CYP3A4 BMS-582949 displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases that include serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. BMS-582949 displays a p38α IC50 of 13 nM and a cellular TNFα IC50 of 50 nM. |
|---|---|---|
| In Vivo | BMS-582949 (5-100 mg/kg, orally) is effective in both the acute murine model of inflammation and rat adjuvant arthritis model despite its slightly reduced potency. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2576 mL | 11.2882 mL | 22.5764 mL | 45.1528 mL |
| 5mM | 0.4515 mL | 2.2576 mL | 4.5153 mL | 9.0306 mL |
| 10mM | 0.2258 mL | 1.1288 mL | 2.2576 mL | 4.5153 mL |
| 20mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.2576 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.