Bleomycin Sulfate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1350	In Stock
500mg	$2050	In Stock
1g	$3075	In Stock

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Cat #: V1424 CAS #: 9041-93-4 Purity ≥ 98%

Description: Bleomycin Sulfate (also known as NSC125066; NSC-125066; BLEO-cell; Bleolem; Blenoxane; Blanoxan), the sulfate salt of Bleomycin, is a glycopeptide antibiotic and an anticancer agent approved for treating a variety of cancers including Hodgkin's lymphoma, non-Hodgkin's lymphoma, ovarian cancer, testicular cancer, and cervical cancer.

References: Corboz MR, et al. Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats. Pulm Pharmacol Ther. 2018 Apr;49:95-103.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1512.62
Molecular Formula	C55H85N17O25S4
CAS No.	9041-93-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (66.1 mM)r
	Water: 100 mg/mL (66.1 mM)r
	Ethanol:<1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	NSC-125066; BLEO; BLM; NSC 125066; BLEO cell; BLEO-cell; NSC125066; BLEOcell; Bleolem; Bleomycin sulfate; Trade name: Blenoxane. Blanoxan Chemical Name: (3-(2'-((3S,6R,7S,8S,11S)-1-(6-amino-2-((S)-3-amino-1-(((S)-2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidin-4-yl)-3-((R)-(((2R,3S,4S,5S,6S)-3-(((2R,3S,4S,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)(1H-imidazol-4-yl)methyl)-7-hydroxy-11-((R)-1-hydroxyethyl)-6,8-dimethyl-1,4,9,12-tetraoxo-2,5,10,13-tetraazapentadecan-15-yl)-[2,5'-bithiazole]-4-carboxamido)propyl)dimethylsulfonium hydrogensulfate SMILES Code: C[S+](CCCNC(C1=CSC(C2=CN=C(CCNC([C@H]([C@H](O)C)NC([C@@H](C)[C@H](O)[C@@H](C)NC([C@H]([C@@H](O[C@H]3[C@@H](O[C@@H]4[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H](CO)O3)C5=CNC=N5)NC(C6=NC([C@@H](NC[C@H](N)C(N)=O)CC(N)=O)=NC(N)=C6C)=O)=O)=O)=O)S2)=N1)=O)C.O=S(O)([O-])=O

Protocol	In Vivo	Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study
	Animal model	Male Fischer 344 rats, 8-10 week old, weighing 150-250 g
	Dosages	3.5-4 mg/kg
	Administration	Intra-tracheal

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.6611 mL	3.3055 mL	6.6110 mL	13.2221 mL
5mM	0.1322 mL	0.6611 mL	1.3222 mL	2.6444 mL
10mM	0.0661 mL	0.3306 mL	0.6611 mL	1.3222 mL
20mM	0.0331 mL	0.1653 mL	0.3306 mL	0.6611 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.