Birinapant (TL32711)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $380 | In Stock |
| 250mg | $620 | In Stock |
| 500mg | $930 | In Stock |
: Cat #: V0051 CAS #: 1260251-31-7 Purity ≥ 98%
Description: Birinapant (TL32711; TL-32711; TL 32711) is a novel and potent bivalent peptidomimetic of SMAC (second mitochondrial-derived activator of caspases) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins.
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| Molecular Weight (MW) | 806.94 |
|---|---|
| Molecular Formula | C42H56F2N8O6 |
| CAS No. | 1260251-31-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (123.9 mM)r |
| Water:<1 mg/mL (slightly soluble or insoluble)r | |
| Ethanol: 55 mg/mL (68.1 mM) | |
| Solubility In Vivo | 15% Captisol: 15mg/mL |
| SMILES Code | C[C@H](NC)C(N[C@@H](CC)C(N1[C@H](CC2=C(C(N3)=C(C[C@H]4N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C4)C5=C3C=C(F)C=C5)NC6=C2C=CC(F)=C6)C[C@H](O)C1)=O)=O |
| Synonyms | SMAC mimetic; Birinapant; TL32711; TL-32711; TL 32711; |
| Protocol | In Vitro | Birinapant (TL32711) (30-10000 nM; 24 hours) significantly decreases the viability of SUM190 cells in a dose-dependent manner. Birinapant (TL32711) binds with high affinity to the isolated BIR3 domains of cIAP1, cIAP2, and XIAP and the single BIR domain of ML-IAP and rapidly degrades TRAF2-bound cIAP1 and cIAP2 thereby inhibiting TNF-mediated NF-κB activation. Birinapant (TL32711) (30-1000 nM; 4 hours) shows a significant decrease in cIAP1 levels and enhanced PARP cleavage, and induces apoptosis. |
|---|---|---|
| In Vivo | Birinapant (TL32711) (30 mg/kg; i.p.; every third day (*5)) shows antitumor efficacy and are devoid of overt toxicity in preclinical models. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.2392 mL | 6.1962 mL | 12.3925 mL | 24.7850 mL |
| 5mM | 0.2478 mL | 1.2392 mL | 2.4785 mL | 4.9570 mL |
| 10mM | 0.1239 mL | 0.6196 mL | 1.2392 mL | 2.4785 mL |
| 20mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.2392 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.