BIRB 796 (Doramapimod)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $490 | In Stock |
| 1g | $810 | In Stock |
| 5g | $2050 | In Stock |
: Cat #: V0477 CAS #: 285983-48-4 Purity ≥ 98%
Description: BIRB 796 (also known as doramapimod) is a novel, orally bioactive, and highly potent pan-p38 MAPK inhibitor with potential anti-inflammatory activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 527.66 |
|---|---|
| Molecular Formula | C31H37N5O3 |
| CAS No. | 285983-48-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 106 mg/mL (200.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 106 mg/mL (200.9 mM) | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL |
| SMILES Code | O=C(NC1=C2C=CC=CC2=C(OCCN3CCOCC3)C=C1)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C |
| Synonyms | BIRB796; BIRB-796; Doramapimod; BIRB 796 |
| Protocol | In Vitro | Doramapimod (BIRB 796) is usually associated with inflammation because of its role in T-cell proliferation and cytokine production. |
|---|---|---|
| In Vivo | The mean xenograft weigh of Doramapimod (BIRB 796) is lighter than control. The inhibition rate of Doramapimod is 1.93%. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8952 mL | 9.4758 mL | 18.9516 mL | 37.9032 mL |
| 5mM | 0.3790 mL | 1.8952 mL | 3.7903 mL | 7.5806 mL |
| 10mM | 0.1895 mL | 0.9476 mL | 1.8952 mL | 3.7903 mL |
| 20mM | 0.0948 mL | 0.4738 mL | 0.9476 mL | 1.8952 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.