Bioymifi
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1280 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V12729 CAS #: 1420071-30-2 Purity ≥ 98%
Description: Bioymifi is an DR5 activator (Kd = 1.2 µM; IC50 = 2 µM).
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| Molecular Weight (MW) | 494.32 |
|---|---|
| Molecular Formula | C22H12BrN3O4S |
| CAS No. | 1420071-30-2 |
| SMILES Code | O=C1NC(C2=C1C=CC(C3=CC=C(/C=C(SC(N4C5=CC=C(Br)C=C5)=N)/C4=O)O3)=C2)=O |
| Synonyms | Bioymifi |
| Protocol | In Vitro | Bioymifi induces apoptosis via death receptor DR5. Bioymifi promotes DR5 aggregation and activation. Bioymifi shares the same DR5-dependent extrinsic apoptotic pathway with TRAIL. Binding of bioymifi to DR5 recruits FADD, which in turn engages with the apical caspase-8 to form death-inducing signaling complex (DISC) Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments. Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0230 mL | 10.1149 mL | 20.2298 mL | 40.4596 mL |
| 5mM | 0.4046 mL | 2.0230 mL | 4.0460 mL | 8.0919 mL |
| 10mM | 0.2023 mL | 1.0115 mL | 2.0230 mL | 4.0460 mL |
| 20mM | 0.1011 mL | 0.5057 mL | 1.0115 mL | 2.0230 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.