(+)-Bicuculline
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $450 | Check With Us |
| 2g | $650 | Check With Us |
| 5g | $1000 | Check With Us |
: Cat #: V1287 CAS #: 485-49-4 Purity ≥ 98%
Description: (+)-Bicuculline (BRN-0098786; NSC-32192; BRN0098786; NSC32192), a phthalide-isoquinoline-based natural product isolated from Dicentra cucullaria, is a novel, light-sensitive and competitive antagonist of GABAA receptors with an IC50 of 2 μM.
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- Related Biological Data
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| Molecular Weight (MW) | 367.35 |
|---|---|
| Molecular Formula | C20H17NO6 |
| CAS No. | 485-49-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 21 mg/mL (57.2 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | d-Bicuculline; Bicculine; Bicucullin; BRN 0098786; NSC 32192; BRN0098786; NSC32192; BRN-0098786; NSC-32192 |
| Protocol | In Vitro | BicucuLline ((+)-BicucuLline； d-BicucuLline) (1 and 3 μM) to achieve the maximum reaction of GABA. BicucuLline appears to shift the dose-response curve of GABA parallel to the right without reducing the GABA maximum response, indicating that it is α1β2γ2L GABAA Competitive antagonists of receptors |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7222 mL | 13.6110 mL | 27.2220 mL | 54.4440 mL |
| 5mM | 0.5444 mL | 2.7222 mL | 5.4444 mL | 10.8888 mL |
| 10mM | 0.2722 mL | 1.3611 mL | 2.7222 mL | 5.4444 mL |
| 20mM | 0.1361 mL | 0.6805 mL | 1.3611 mL | 2.7222 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.