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Bezafibrate

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Bezafibrate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10g$450Check With Us
25g$850Check With Us
50g$1275Check With Us
email: [email protected]        [email protected]

Cat #: V0836 CAS #: 41859-67-0 Purity ≥ 99%

Description: Bezafibrate (BM 15075; BM-15075; Benzofibrate; BM15075; Bezalip; Bezatrol; Difaterol; Cedur; Bezafibratum) is an anti-hypertriglyceridemic/lipid-lowering drug acting.

References: Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50.

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Molecular Weight (MW)361.82
Molecular FormulaC19H20ClNO4
CAS No.41859-67-0
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 72 mg/mL (199.0 mM)r
Water: <1 mg/mLr
Ethanol: 18 mg/mL (49.7 mM)
SMILES CodeClC1=CC=C(C(NCCC2=CC=C(OC(C)(C)C(O)=O)C=C2)=O)C=C1
SynonymsBM 15075; BM-15075; Bezafibrate; BM15075; Benzofibrate; Bezalip; Bezatrol; Difaterol; Cedur; Bezafibratum
ProtocolIn VitroBezafibrate is an agonist of PPAR, with EC50s of 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, and 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, respectively.
In VivoBezafibrate (0.5%) markedly reduces plasma lipid and glucose levels, and increases islet area in the pancreas in TallyHo mice. Bezafibrate also improves energy expenditure and metabolic flexibility. Moreover, Bezafibrate ameliorates steatosis, modifies lipid composition and increases mitochondrial mass in the liver.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7638 mL13.8190 mL27.6381 mL55.2761 mL
5mM0.5528 mL2.7638 mL5.5276 mL11.0552 mL
10mM0.2764 mL1.3819 mL2.7638 mL5.5276 mL
20mM0.1382 mL0.6910 mL1.3819 mL2.7638 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.