Azithromycin (CP 62993)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $250 | Check With Us |
| 10g | $1150 | Check With Us |
| 20g | $1725 | Check With Us |
: Cat #: V2272 CAS #: 83905-01-5 Purity ≥ 98%
Description: Azithromycin (also known as CP-62993; XZ-450) is an macrolide antibiotic which acts by inhibiting protein synthesis, and is used for the treatment of bacterial infections.
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| Molecular Weight (MW) | 748.98 |
|---|---|
| Molecular Formula | C38H72N2O12 |
| CAS No. | 83905-01-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (133.5 mM)r |
| Water: < 1 mg/mLr | |
| Ethanol: 100 mg/mL (133.5 mM) | |
| SMILES Code | CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O |
| Synonyms | CP-62993, XZ-450; Azitro; CP 62993; CP62993; Goxal; Odaz; Ribotrex; Toraseptol; Ultreon; XZ450; XZ 450; Zenstavion; Zithromax; Zmax |
| Protocol | In Vitro | Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. |
|---|---|---|
| In Vivo | Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3351 mL | 6.6757 mL | 13.3515 mL | 26.7030 mL |
| 5mM | 0.2670 mL | 1.3351 mL | 2.6703 mL | 5.3406 mL |
| 10mM | 0.1335 mL | 0.6676 mL | 1.3351 mL | 2.6703 mL |
| 20mM | 0.0668 mL | 0.3338 mL | 0.6676 mL | 1.3351 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.