Azasetron HCl (Y-25130)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $950 | Check With Us |
| 1g | $1550 | Check With Us |
| 5g | $3870 | Check With Us |
: Cat #: V1000 CAS #: 123040-16-4 Purity ≥ 98%
Description: Azasetron HCl (formerly Y 25130 HCl; Y-25130; Y25130), an approved antiemetic drug, is a potent and selective antagonist of 5-HT3 receptor with an IC50 of 0.33 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 386.27 |
|---|---|
| Molecular Formula | C17H20ClN3O3.HCl |
| CAS No. | 123040-16-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: 3 mg/mL (7.8 mM)r | |
| Ethanol: <1 mg/mL | |
| Synonyms | Y 25130 HCl; Y-25130; Y25130 |
| Protocol | In Vivo | Azasetron could effectively penetrate through the skin and pass into the systemic circulation |
|---|---|---|
| Animal model | Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old) | |
| Dosages | 0.5 mg/kg. | |
| Administration | I.V. administration via the abdominal vein. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5889 mL | 12.9443 mL | 25.8886 mL | 51.7773 mL |
| 5mM | 0.5178 mL | 2.5889 mL | 5.1777 mL | 10.3555 mL |
| 10mM | 0.2589 mL | 1.2944 mL | 2.5889 mL | 5.1777 mL |
| 20mM | 0.1294 mL | 0.6472 mL | 1.2944 mL | 2.5889 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.