AUT1 | CAS 1311136-84-1

AUT1

This product is for research use only, not for human use. We do not sell to patients.

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250mg	$1500	Check With Us
500mg	$2050	Check With Us
1g	$3075	Check With Us

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Cat #: V11905 CAS #: 1311136-84-1 Purity ≥ 98%

Description: AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents.

References: Rosato-Siri MD, et al. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	341.37
Molecular Formula	C18H19N3O4
CAS No.	1311136-84-1
Synonyms	AUT-1; AUT 1; AUT1

Protocol	In Vitro	AUT1 (1.5, 12.5, and 25 μM) modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50s of 5.33 and 5.31 μM, respectively

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9294 mL	14.6469 mL	29.2937 mL	58.5875 mL
5mM	0.5859 mL	2.9294 mL	5.8587 mL	11.7175 mL
10mM	0.2929 mL	1.4647 mL	2.9294 mL	5.8587 mL
20mM	0.1465 mL	0.7323 mL	1.4647 mL	2.9294 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.