Atorvastatin Epoxy Tetrahydrofuran Impurity
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $5120 | To Be Confirmed |
| 200mg | $7680 | To Be Confirmed |
| 500mg | $12960 | To Be Confirmed |
: Cat #: V38962 CAS #: 873950-19-7 Purity ≥ 99%
Description: Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, which is an anti-hyperlipidemic drug and selective inhibitor of HMG-CoA reductase.
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| Molecular Weight (MW) | 449.47 |
|---|---|
| Molecular Formula | C26H24FNO5 |
| CAS No. | 873950-19-7 |
| Synonyms | Atorvastatin Epoxy Tetrahydrofuran Impurity; |
| Protocol | In Vitro | Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2248 mL | 11.1242 mL | 22.2484 mL | 44.4969 mL |
| 5mM | 0.4450 mL | 2.2248 mL | 4.4497 mL | 8.8994 mL |
| 10mM | 0.2225 mL | 1.1124 mL | 2.2248 mL | 4.4497 mL |
| 20mM | 0.1112 mL | 0.5562 mL | 1.1124 mL | 2.2248 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.