Atorvastatin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $250 | To Be Confirmed |
| 10g | $450 | To Be Confirmed |
| 20g | $675 | To Be Confirmed |
: Cat #: V11849 CAS #: 134523-00-5 Purity ≥ 99%
Description: Atorvastatin (CI-981; CI981; Tozalip; Torvast; Cardyl; Lipitor; liptonorm) is an approved blockbuster drug of the statin class used as an LDL cholesterol-lowering/hypolipidemic medication.
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- Related Biological Data
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| Molecular Weight (MW) | 558.64 |
|---|---|
| Molecular Formula | C33H35FN2O5 |
| CAS No. | 134523-00-5 |
| SMILES Code | O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C1C(C)C |
| Synonyms | Atorvastatin; Lipilou; Tozalip; Torvast; Cardyl; |
| Protocol | In Vitro | Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation. |
|---|---|---|
| In Vivo | Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7901 mL | 8.9503 mL | 17.9006 mL | 35.8012 mL |
| 5mM | 0.3580 mL | 1.7901 mL | 3.5801 mL | 7.1602 mL |
| 10mM | 0.1790 mL | 0.8950 mL | 1.7901 mL | 3.5801 mL |
| 20mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 1.7901 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.