Aspirin (Acetylsalicylic Acid; ASA)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100g	$300	Check With Us
200g	$400	Check With Us
500g	$625	Check With Us

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Cat #: V1062 CAS #: 50-78-2 Purity ≥ 98%

Description: Aspirin (Acetylsalicylic acid; ASA; Acetylin; Claradin), a widely used analgesic and a salicylate analog, is a non-selective and covalent/irreversible inhibitor of COX1 and COX2 enzymes with a broad range of biological activities such as anti-inflammatory and pain relieving effects.

References: Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972 Aug;22(4):672-5.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	180.16
Molecular Formula	C9H8O4
CAS No.	50-78-2
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 36 mg/mL (199.8 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 36 mg/mL (199.8 mM)
Solubility In Vivo	4% DMSO+PBS: 10mg/mL
SMILES Code	OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(F)=NC(N)=C3N=C2)O1
Synonyms	Acetylsalicylic acid; Acetylin; Claradin

Protocol	In Vivo	Aspirin (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats
	Animal model	Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 ml/kg of a 20 % aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)
	Dosages	5, 25, 50, 100 and 150 mg/kg

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	5.5506 mL	27.7531 mL	55.5062 mL	111.0124 mL
5mM	1.1101 mL	5.5506 mL	11.1012 mL	22.2025 mL
10mM	0.5551 mL	2.7753 mL	5.5506 mL	11.1012 mL
20mM	0.2775 mL	1.3877 mL	2.7753 mL	5.5506 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.