ASP4132 tosylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1600 | Check With Us |
| 500mg | $2300 | Check With Us |
| 1g | $3450 | Check With Us |
: Cat #: V2166 CAS #: 1640294-30-9 Purity ≥ 98%
Description: ASP4132 tosylate (ASP-4132) is an oral bioavailable AMPK activator (EC50 = 18 nM) with potential anticancer activity.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 937.06 |
|---|---|
| Molecular Formula | C46H51F3N6O8S2 |
| CAS No. | 1640294-30-9 |
| SMILES Code | O=C(C1=NC2=CC=C(C3CCN(CC4=CC=C(OC)N=C4)CC3)C=C2N1)N5CCN(CC6=CC=C(C(F)(F)F)C=C6)CC5.OS(=O)(C7=CC=C(C)C=C7)=O.OS(=O)(C8=CC=C(C)C=C8)=O |
| Synonyms | ASP4132 tosylate; ASP 4132; ASP-4132; ASP4132 |
| Protocol | In Vitro | ASP4132 shows relatively weak antiproliferative activity against SK-BR-3 (IC50>3 μM). ASP4132 shows comparable cell growth inhibitory (IC50=0.014 μM) activity against MDA-MB-453 breast cancer cell. |
|---|---|---|
| In Vivo | ASP4132 is stable in human liver microsomes (HLM CLint, vitro=61 mL/min•kg). ASP4132 (1 mg/kg; IV or PO) has a T1/2 of 3.6 hours, a CLtot of 19 mL/min•kg, and a Vss of 4.6 L/kg for rats for IV. ASP4132 (0.5-8 mg/kg; PO; once daily; for 21 days) causes the tumor growth inhibition and regression. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.0672 mL | 5.3358 mL | 10.6717 mL | 21.3434 mL |
| 5mM | 0.2134 mL | 1.0672 mL | 2.1343 mL | 4.2687 mL |
| 10mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.1343 mL |
| 20mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.0672 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.