ARRY-797

This product is for research use only, not for human use. We do not sell to patients.

ARRY-797
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
2mg$70In Stock
5mg$100In Stock
10mg$170In Stock
25mg$320In Stock
50mg$550In Stock
100mg$880In Stock

Cat #: V3316 CAS #: 1036404-17-7 Purity ≥ 98%

Description: ARRY-797 (also known as ARRY 371797) is a novel, potent and selective inhibitor of p38α (p38 mitogen-activated protein kinase). ARRY-371797 Inhibits LPS-Induced IL-6 and In Vivo Growth of RPMI-8226 Human Multiple Myeloma Cells. Treatment of Lmna(H222P/H222P) mice with the p38α inhibitor ARRY-371797 prevented left ventricular dilatation and deterioration of fractional shortening compared with placebo-treated mice but did not block the expression of collagen genes involved in cardiac fibrosis. These results demonstrate that three different branches of the MAP kinase signaling pathway with overlapping consequences are involved in the pathogenesis of cardiomyopathy caused by LMNA mutations. They further suggest that pharmacological inhibition of p38α may be useful in the treatment of this disease.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)416.47
Molecular FormulaC22H26F2N4O2
CAS No.1036404-17-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10mM
Water: N/A
Ethanol: N/A
SMILES CodeO=C(C1=CC2=C(C=C1OC3=CC=C(F)C=C3F)C=NN2CC(C)C)NCCN(C)C
SynonymsARRY-371797; ARRY 371797; ARRY371797; ARRY-797; ARRY 797; ARRY797
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4011 mL12.0057 mL24.0113 mL48.0227 mL
5mM0.4802 mL2.4011 mL4.8023 mL9.6045 mL
10mM0.2401 mL1.2006 mL2.4011 mL4.8023 mL
20mM0.1201 mL0.6003 mL1.2006 mL2.4011 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.