Apricitabine [(-)-BCH10652; (-)-dOTC; AVX754; BCH10618; SPD754]

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1250	Check With Us
500mg	$1850	Check With Us
1g	$2775	Check With Us

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Cat #: V8732 CAS #: 160707-69-7 Purity ≥ 99%

Description: Apricitabine [(-)-BCH-10652; (-)-dOTC; AVX-754; BCH-10618; SPD-754] is a highly potent, selective and orally bioactive HIV-1 reverse transcriptase (RT) inhibitor with Ki of 0.08 μM, belonging to the nucleoside reverse transcriptase inhibitor (NRTI) class of anti-HIV agents.

References: de Muys JM, et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.Antimicrob Agents Chemother. 1999 Aug;43(8):1835-44.

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Molecular Weight (MW)	229.26
Molecular Formula	C8H11N3O3S
CAS No.	160707-69-7
SMILES Code	O=C1N=C(N)C=CN1[C@@H]2S[C@H](CO)OC2
Synonyms	(-)-BCH10652; AVX754; BCH10618; SPD754; Apricitabine; (-)-BCH-10652; (-)-dOTC; AVX-754; BCH-10618; SPD-754;

Protocol	In Vitro	Apricitabine (SPD754; AVX754) is against clinical isolates of HIV-1 in cultured PBMCs with IC50 values of 0.2 μM, 1.45 μM, 2.2 μM and 2.4 μM for HIV-1RF, Wild type, 3TC resistant, 3TC and AZT resistant, respectively.
Protocol	In Vivo	Apricitabine (SPD754; AVX754) (oral adminstation; 10 mg/kg; once a day) exhibits a good oral bioavailability of 68% for males and 69.4% for females rats. And the T1/2, AUC0–∞, Tmax, Cmax are 62.2 mins, 157.4 μg/min/ml and 37.3 mins, 1.16 μg/ml in female rats.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.3619 mL	21.8093 mL	43.6186 mL	87.2372 mL
5mM	0.8724 mL	4.3619 mL	8.7237 mL	17.4474 mL
10mM	0.4362 mL	2.1809 mL	4.3619 mL	8.7237 mL
20mM	0.2181 mL	1.0905 mL	2.1809 mL	4.3619 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.