Home > Signaling Pathways>Neuronal Signaling>Dopamine Receptor >Amantadine HCl
Amantadine HCl

This product is for research use only, not for human use. We do not sell to patients.

Amantadine HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50g$180Check With Us
100g$280Check With Us
200g$420Check With Us
email: [email protected]        [email protected]

Cat #: V1257 CAS #: 665-66-7 Purity ≥ 98%

Description: Amantadine HCl (EXP-105-1; GP 38026; ADS5102; Influenol; Midantan; Midantane; Mydantane; NSC 83653; Symadine; Symmetrel; Trivaline; Virasol; Viregyt; Virofral; Virosol), the hydrochloride salt of amantadine, is an approved medication used to treat or prevent infections of the respiratory tract caused by a certain virus.

References: Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. 

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)187.7
Molecular FormulaC10H17N.HCl
CAS No.665-66-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 38 mg/mL (202.5 mM)r
Water: 38 mg/mL (202.5 mM)r
Ethanol: 38 mg/mL (202.5 mM)
Solubility In VivoChemical Name: adamantan-1-amine hydrochloride InChi Key: WOLHOYHSEKDWQH-UHFFFAOYSA-N InChi Code: InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H SMILES Code: NC12CC3CC(C2)CC(C3)C1.[H]Cl
SynonymsADS-5102; EXP 105-1; EXP-105-1; GP 38026; ADS5102; EXP-105-1; EXP-105-1; GP38026; ADS 5102; EXP105-1; EXP-105-1; GP-38026; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; Influenol; Midantan; Midantane; Mydantane; NSC 83653; Amantadine HCl; Symadine; Symmetrel; Trivaline; Virasol; Viregyt; Virofral; Virosol; 1-adamantanamine HCl
ProtocolIn VivoAmantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment
Animal modelFischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)
Dosages25 mg/kg
AdministrationIP, once daily for 3 days (the first dose at 15 min before surgery)
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM5.3277 mL26.6383 mL53.2765 mL106.5530 mL
5mM1.0655 mL5.3277 mL10.6553 mL21.3106 mL
10mM0.5328 mL2.6638 mL5.3277 mL10.6553 mL
20mM0.2664 mL1.3319 mL2.6638 mL5.3277 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.