ADU-S100 disodium salt
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $4050 | To Be Confirmed |
| 200mg | $6075 | To Be Confirmed |
| 500mg | $10250 | To Be Confirmed |
: Cat #: V32421 CAS #: 1638750-95-4 Purity ≥ 99%
Description: ADU-S100 disodium salt (MIW815; MIW-815; ML RR-S2-CDA) is the first agonist of stimulator of interferon genes (STING), with immunomodulatory and antitumor activities.
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| Molecular Weight (MW) | 734.51 |
|---|---|
| Molecular Formula | C20H22N10Na2O10P2S2 |
| CAS No. | 1638750-95-4 |
| SMILES Code | O[C@@H]1[C@@H](CO[P@@]([S-])(O[C@H]2[C@@H](O)[C@H](N3C4=C(C(N)=NC=N4)N=C3)O[C@@H]2CO5)=O)O[C@@H](N6C7=C(C(N)=NC=N7)N=C6)[C@@H]1O[P@@]5([S-])=O.[Na+].[Na+] |
| Synonyms | MIW815; MIW-815; MIW 815; ADU-S100; ADU S100; ADUS100; ML RR-S2 CDA sodium salt; |
| Protocol | In Vitro | ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTINGREF and hSTINGQ alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP. |
|---|---|---|
| In Vivo | ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3615 mL | 6.8073 mL | 13.6145 mL | 27.2290 mL |
| 5mM | 0.2723 mL | 1.3615 mL | 2.7229 mL | 5.4458 mL |
| 10mM | 0.1361 mL | 0.6807 mL | 1.3615 mL | 2.7229 mL |
| 20mM | 0.0681 mL | 0.3404 mL | 0.6807 mL | 1.3615 mL |
The molarity calculator equation
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.