Adapalene | CAS 106685-40-9

Adapalene

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
2g	$580	Check With Us
5g	$1050	Check With Us
10g	$1575	Check With Us

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Cat #: V0945 CAS #: 106685-40-9 Purity ≥ 98%

Description: Adapalene (Differin; Adaferin; CD271; Adapaleno; ADAPALENE; Adapalenum), structurallysimilar to vitamin A, is a synthetic, retinoic acid analog acting as a dual RAR and RXR agonist with potential anticancer activity.

References: Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	412.52
Molecular Formula	C28H28O3
CAS No.	106685-40-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 8 mg/mL (19.4 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
Synonyms	Differin; Adaferin; CD271; Adapaleno; ADAPALENE; Adapalenum; CD-271; CD 271.

Protocol	In Vitro	Adapalene (10-6-10-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC50 of 2.5 nM.
Protocol	In Vivo	Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4241 mL	12.1206 mL	24.2412 mL	48.4825 mL
5mM	0.4848 mL	2.4241 mL	4.8482 mL	9.6965 mL
10mM	0.2424 mL	1.2121 mL	2.4241 mL	4.8482 mL
20mM	0.1212 mL	0.6060 mL	1.2121 mL	2.4241 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.