Acetaminophen (Paracetamol; APAP)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100g	$150	Check With Us
200g	$250	Check With Us
500g	$380	Check With Us

: [email protected] [email protected]

Cat #: V1043 CAS #: 103-90-2 Purity ≥ 98%

Description: Acetaminophen (APAP; NSC-3991; NSC-109028; Paracetamol, Tylenol; 4'-Hydroxyacetanilide; 4-Acetamidophenol), a pain reliever and a fever reducer, is a potent and non-selective COX inhibitor with IC50s of 113.7 μM and 25.8 μM for COX-1 and COX-2, respectively.

References: Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	151.16
Molecular Formula	C8H9NO2
CAS No.	103-90-2
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 30 mg/mL (198.5 mM)rr
	Water: 13 mg/mL (86.0 mM)rr
	Ethanol: 30 mg/mL (198.5 mM)
SMILES Code	CC(NC1=CC=C(O)C=C1)=O
Synonyms	4'-Hydroxyacetanilide; 4-Acetamidophenol; Paracetamol, Tylenol; Acetaminophen; Tylenol; 4-Acetamidophenol; APAP; 4'-Hydroxyacetanilide; NSC 3991; NSC 109028; Paracetamol.

Protocol	In Vivo	Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p<0.001) liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) compared with normal group. Conversely, effects of pretreatment with different doses of citral (125, 250, and 500 mg/kg) exhibited a significant (p<0.05) decrease in serum activities of ALT (91.79%, 93.07%, and 95.61%, resp.), AST (93.40%, 91.89%, and 96.52%, resp.), ALP (39.29%, 37.07%, and 59.80%, resp.), and γGT (92.83%, 91.59%, and 93.0%, resp.), when compared to the Acetaminophen group. Similar results were found in pretreatment with SLM on the activity of ALT (95.90%), AST (95.03%), ALP (70.52%), and γGT (92.69%)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	6.6155 mL	33.0775 mL	66.1551 mL	132.3101 mL
5mM	1.3231 mL	6.6155 mL	13.2310 mL	26.4620 mL
10mM	0.6616 mL	3.3078 mL	6.6155 mL	13.2310 mL
20mM	0.3308 mL	1.6539 mL	3.3078 mL	6.6155 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.