Acemetacin (K-708; TVX 1322)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$660	Check With Us
100g	$1020	Check With Us
200g	$1530	Check With Us

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Cat #: V1057 CAS #: 53164-05-9 Purity ≥ 98%

Description: Acemetacin (K708; Acemetacin; Rantudil; K-708; TVX 1322; TVX-1322) is a potent non-steroidal anti-inflammatory drug (NSAID) and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor with potential anti-inflammatory activity.

References: Tavares IA, et al. Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage. J Gastroenterol Hepatol. 1998 Nov;13(S3):S190-S192.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	415.82
Molecular Formula	C21H18ClNO6
CAS No.	53164-05-9
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 83 mg/mL (199.6 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 58 mg/mL (139.5 mM)
SMILES Code	O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Synonyms	TVX1322; K-708; Acemetacin; Rantudil; K 708; TVX 1322; TVX-1322; K708

Protocol	In Vivo	Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice
	Animal model	DSS-induced acute colitis in C57BL/6 mice
	Dosages	4 mg/kg;16 mg/kg
	Administration	Oral administration; 4 mg/kg/16 mg/kg; 9 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4049 mL	12.0244 mL	24.0489 mL	48.0977 mL
5mM	0.4810 mL	2.4049 mL	4.8098 mL	9.6195 mL
10mM	0.2405 mL	1.2024 mL	2.4049 mL	4.8098 mL
20mM	0.1202 mL	0.6012 mL	1.2024 mL	2.4049 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.