AC1903
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | Check With Us |
| 250mg | $1250 | Check With Us |
| 500mg | $1875 | Check With Us |
: Cat #: V10018 CAS #: 831234-13-0 Purity ≥ 99%
Description: AC1903 is a novel, potent and specific TRPC5 channel blocker with podocyte-protective activity, suppressing severe proteinuria and prevent podocyte loss.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 303.36 |
|---|---|
| Molecular Formula | C19H17N3O |
| CAS No. | 831234-13-0 |
| SMILES Code | C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4 <br/> |
| Protocol | In Vitro | TRPC5 is a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 (0-100 µM) blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)–induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations in Patch-clamp electrophysiology experiments. The ICIC50 values of ML204 (HY-12949) (IC50=13.6 μM) and AC1903 (IC50=14.7 μM) are nearly equipotent in human embryonic kidney 293 (HEK-293) cells expressing TRPC5 |
|---|---|---|
| In Vivo | AC1903 (intraperitoneal injection; 50 mg/kg; twice per day; 7 days) significantly suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease | |
| Animal model | Hypertension-induced focal segmental glomerulosclerosis (FSGS) model in Dahl salt-sensitive rats | |
| Dosages | 50 mg/kg | |
| Administration | Intraperitoneal injection; 50 mg/kg; twice per day; 7 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2964 mL | 16.4821 mL | 32.9641 mL | 65.9283 mL |
| 5mM | 0.6593 mL | 3.2964 mL | 6.5928 mL | 13.1857 mL |
| 10mM | 0.3296 mL | 1.6482 mL | 3.2964 mL | 6.5928 mL |
| 20mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 3.2964 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.