ABT-510 TFA salts

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1100	In Stock
200mg	$1650	In Stock
500mg	$2780	In Stock

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Cat #: V9987 CAS #: 251579-55-2 Purity ≥ 98%

Description: ABT-510 TFA, the trifluoroacetic acid (TFA) salt form of ABT-510 which is a TSP-1 mimetic drug, is a synthetic peptide composed of nine-amino acids, it acts by mimicking the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1).

References: Greenaway J, et al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8(1):64-74.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	994.23
Molecular Formula	C46H83N13O11
CAS No.	251579-55-2
SMILES Code	O=C([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CCC)NC([C@H]([C@@H](O)C)NC([C@@H]([C@@H](C)CC)NC([C@H](C(C)C)NC(CNC(CN(C)C(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)NCC
Synonyms	ABT510; ABT 510; ABT-510

Protocol	In Vitro	ABT-510 (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID8 cells and (50 nM; 24 h) increases the incidence of apoptosis in the human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3.
Protocol	In Vivo	ABT-510 (100 mg/kg; I.p.; single daily for 90 days) induces cells apoptosis in vivo. ABT-510 (100 mg/kg; i.p.; single daily for 90 days) leads to a significant reduction in tumor size, ascites fluid volume, and secondary lesion dissemination in mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.0058 mL	5.0290 mL	10.0580 mL	20.1161 mL
5mM	0.2012 mL	1.0058 mL	2.0116 mL	4.0232 mL
10mM	0.1006 mL	0.5029 mL	1.0058 mL	2.0116 mL
20mM	0.0503 mL	0.2515 mL	0.5029 mL	1.0058 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.