ABT-072
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3675 | To Be Confirmed |
| 200mg | $5510 | To Be Confirmed |
| 500mg | $9300 | To Be Confirmed |
: Cat #: V4403 CAS #: 1132936-00-5 Purity ≥ 98%
Description: ABT-072 is a novel and potent nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus (HCV).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 469.55 |
|---|---|
| Molecular Formula | C24H27N3O5S |
| CAS No. | 1132936-00-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | CS(=O)(NC1=CC=C(/C=C/C2=CC(N(C(N3)=O)C=CC3=O)=CC(C(C)(C)C)=C2OC)C=C1)=O |
| Synonyms | ABT-072; ABT 072; ABT072. |
| Protocol | In Vitro | ABT-072 is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases. |
|---|---|---|
| In Vivo | ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) shows good PK properties. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1297 mL | 10.6485 mL | 21.2970 mL | 42.5940 mL |
| 5mM | 0.4259 mL | 2.1297 mL | 4.2594 mL | 8.5188 mL |
| 10mM | 0.2130 mL | 1.0648 mL | 2.1297 mL | 4.2594 mL |
| 20mM | 0.1065 mL | 0.5324 mL | 1.0648 mL | 2.1297 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.