Inarigivir soproxil, formerly known as SB 9200, is a potent antiviral agent.

Ledipasvir D-tartrate (also known as GS5885 D-tartrate), the D-tartrate salt of Ledipasvir, is an HCV NS5A polymerase inhibitor that has been approved for use in combination with sofosbuvir (trade name Harvoni) for the treatment of hepatitis C virus infection. As an inhibitor of the hepatitis C virus NS5A, it has EC50s of 34 pM and […]

Dasabuvir (formerly known as ABT-333; ABT333; trade name Exviera, Viekira Pak, Viekira XR) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) NS5B gene. It inhibited recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC50 values between 2.2 and 10.7 nM, and was […]

Nesbuvir (VB-19796 ; VB19796; HC-V796; HCV796) is a novel and potent NS5B (nonstructural protein 5B) polymerase inhibitor that has the potential for HCV treatment.

PSI-6130 (R-1656) is a novel, potent and selective inhibitor of HCV NS5B polymerase which inhibits HCV replication with a mean IC50 of 0.6 μM. PSI-6130 is a cytidine analogue with potent and selective anti-hepatitis C virus (HCV) activity in the subgenomic HCV replicon assay, 90% effective concentration (EC90)=4.6 +/- 2.0 microM. The spectrum of activity […]

Glecaprevir (previously called ABT493; A1282576; ABT-493; A-1282576; Mavyret) is a novel and potent inhibitor of the hepatitis C virus nonstructural protein 3/4A protease (HCV NS3/4A) approved as anti-HCV drug in co-formulation with an HCV NS5A inhibitor pibrentasvir. It inhibits HCV NS3/4A protease with IC50 ranging from 3.5 to 11.3 nM. In August 2017, the U.S. […]

Artemisinin (also known as qinghaosu in Chinese; NSC-369397), discovered by Tu Youyou (2015 Nobel Prize winner in Medicine) team, is a naturally occurring anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants.

Grazoprevir hydrate (previously known as MK 5172; MK-5172; MK5172; Zepatier), the mono-hydrated form of grazoprevir, is a second generation inhibitor of HCV (Hepatitis C Virus) NS3/4A Protease and a marketed broad spectrum anti-HCV drug with activity across genotypes and resistant variants. It inhibits HCV genotype 1a, 1B, and 4 with IC50 values of 7pM, 4pM, […]

Deapioplatycodin D is a novel and potent triterpenoid saponin.

Merimepodib, formerly known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM.