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: Cat #: V3050 CAS #: 1185388-35-5 Purity ≥ 98%
Description: A110 is a novel, potent and selective inhibitor of IMPDHs. It binds to the NAD(+) cofactor site and forms a ternary complex with IMP. In combination with steady-state initial rate studies, the results show that the inhibitor A110 binds with high affinity (Kd ≈ 50 nM) predominantly to the covalent intermediate on the reaction pathway. Only a weak binding interaction (Kd ≈ 1 μM) is observed between the inhibitor and E·IMP. Thus, the E·IMP·A110 ternary complex, observed by X-ray crystallography, is largely kinetically irrelevant.
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| Molecular Weight (MW) | 366.81 |
|---|---|
| Molecular Formula | C19H15ClN4O2 |
| CAS No. | 1185388-35-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mM |
| Water: <1mg/mL | |
| Ethanol: <1mg/mL | |
| Synonyms | A110; A 110; A-110 |
| Protocol | In Vitro | In vitro activity: Kinase Assay: Cell Assay: |
|---|
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7262 mL | 13.6310 mL | 27.2621 mL | 54.5241 mL |
| 5mM | 0.5452 mL | 2.7262 mL | 5.4524 mL | 10.9048 mL |
| 10mM | 0.2726 mL | 1.3631 mL | 2.7262 mL | 5.4524 mL |
| 20mM | 0.1363 mL | 0.6816 mL | 1.3631 mL | 2.7262 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.