A 438079
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $930 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V28878 CAS #: 899507-36-9 Purity ≥ 99%
Description: A-438079 HCl is a novel, potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
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| Molecular Weight (MW) | 306.15 |
|---|---|
| Molecular Formula | C₁₃H₉Cl₂N₅ |
| CAS No. | 899507-36-9 |
| Synonyms | <span id="xn_c_prodv_37_conT1_t">A-438079; A 438079 |
| Protocol | In Vitro | In 1321N1 cells stably expressing rat P2X7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A 438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM |
|---|---|---|
| In Vivo | A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2664 mL | 16.3319 mL | 32.6637 mL | 65.3275 mL |
| 5mM | 0.6533 mL | 3.2664 mL | 6.5327 mL | 13.0655 mL |
| 10mM | 0.3266 mL | 1.6332 mL | 3.2664 mL | 6.5327 mL |
| 20mM | 0.1633 mL | 0.8166 mL | 1.6332 mL | 3.2664 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.