A 33853 | CAS 80148-45-4

A 33853

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Cat #: V3095 CAS #: 80148-45-4 Purity ≥ 98%

Description: A 33853 (A33853; A-33853), a tetraacetyl that contains an anhydride moiety, is an antibiotic originally isolated from culture broth of Streptomyces sp. The synthetic analog of it was screened for the inhibition of L. donovani, T. b. rhodesiense, T. cruzi, and P. falciparum cultures followed by determination of IC(50) in L. donovani and cytotoxicity on L6 cells revealed one of the analogs compound 31 to be 3-fold more active than miltefosine, a known antileishmanial drug. Other analogs of A 33853 selectively inhibited L. donovani at nanomolar concentrations and showed much lower cytotoxicity.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	391.34
Molecular Formula	C20H13N3O6
CAS No.	80148-45-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Synonyms	A 33853; A33853; A-33853

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5553 mL	12.7766 mL	25.5532 mL	51.1065 mL
5mM	0.5111 mL	2.5553 mL	5.1106 mL	10.2213 mL
10mM	0.2555 mL	1.2777 mL	2.5553 mL	5.1106 mL
20mM	0.1278 mL	0.6388 mL	1.2777 mL	2.5553 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.