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Cat #: V3086 CAS #: 360551-71-9 Purity ≥ 98%
Description: A-304121, a piperazine amide, is a potent H3R antagonist. A-304121 potently antagonize native H3Rs by blocking histamine inhibition of potassium-evoked [3H]histamine release from rat brain cortical synaptosomes (pKb values = 8.6 and 9.3) and (R)-alpha-MeHA reversal of electric field-stimulated guinea pig ileum contractions (pA2 values = 7.1 and 8.3). A-304121 is also more efficacious inverse agonists in reversing basal guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding at the human H3R (pEC50 values = 5.7 and 7.0) than are the imidazole antagonists. These novel and selective piperazine amides represent useful leads for the development of H3R antagonist therapeutic agents.
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Molecular Weight (MW) | 359.47 |
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Molecular Formula | C20H29N3O3 |
CAS No. | 360551-71-9 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 10 mM |
Water: N/A | |
Ethanol: N/A | |
Synonyms | A-304121; A 304121 |
Solvent volume to be added | Mass (the weight of a compound) | |||
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Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.7819 mL | 13.9094 mL | 27.8187 mL | 55.6375 mL |
5mM | 0.5564 mL | 2.7819 mL | 5.5637 mL | 11.1275 mL |
10mM | 0.2782 mL | 1.3909 mL | 2.7819 mL | 5.5637 mL |
20mM | 0.1391 mL | 0.6955 mL | 1.3909 mL | 2.7819 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.