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Cat #: V3081 CAS #: 483341-15-7 Purity ≥ 98%
Description: A-286501 is a novel and potent carbocyclic nucleoside AK (Adenosine kinase) inhibitor with an IC50 of 0.47 nM and has analgesic and anti-inflammatory activities. It has no significant activity (IC50 >100 microM) at other sites of ADO (Adenosine) interaction (A1, A2A, A3 receptors, ADO transporter, and ADO deaminase) or other (IC50 value >10 microM) neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter reuptake sites and enzymes, including cyclooxygenases-1 and -2. A-286501 showed equivalent potency in the inhibition of AK from several mammalian species and kinetic studies revealed that A-286501 was a reversible and competitive inhibitor with respect to ADO and non-competitive with respect to MgATP2-
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Molecular Weight (MW) | 328.17 |
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Molecular Formula | C11H14BrN5O2 |
CAS No. | 483341-15-7 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 10 mM |
Water: N/A | |
Ethanol: N/A | |
Synonyms | A-286501; A 286501; A286501 |
Protocol | In Vitro | In vitro activity: Kinase Assay: Cell Assay: |
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Solvent volume to be added | Mass (the weight of a compound) | |||
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Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 3.0472 mL | 15.2360 mL | 30.4720 mL | 60.9440 mL |
5mM | 0.6094 mL | 3.0472 mL | 6.0944 mL | 12.1888 mL |
10mM | 0.3047 mL | 1.5236 mL | 3.0472 mL | 6.0944 mL |
20mM | 0.1524 mL | 0.7618 mL | 1.5236 mL | 3.0472 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.