A 26771B | CAS 56448-20-5

A 26771B

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Cat #: V3077 CAS #: 56448-20-5 Purity ≥ 98%

Description: A 26771B is a sixteen-membered macrolide lactone antibiotic (Berkeleylactones) that was originally isolated from Penicillium turbatum. In recent years, promising synthetic derivatives of macrolactone natural product (-)-A26771B have been designed and synthesized both from semisynthesis and total synthesis. Further optimization led to the first synthesis of macrolactam analogs of (-)-A26771B with improved antibacterial activity and metabolic stability. One of the Berkeleylactones exhibited potent antimicrobial activity with low micromolar activity (MIC = 1-2 μg/mL) against four MRSA strains, as well as Bacillus anthracis, Streptococcus pyogenes, Candida albicans, and Candida glabrata.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	382.45
Molecular Formula	C20H30O7
CAS No.	56448-20-5
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO:
	Water:
	Ethanol:
Synonyms	A 26771B; A-26771B; A26771B

Related Biological Data

X-ray crystal structure of berkeleylactone A (1). J Nat Prod. 2017 Apr 28;80(4):1150-1160.

The extension inhibition assay allows the direct monitoring of the formation of stalled ribosome complexes (SRCs) on mRNA. J Nat Prod. 2017 Apr 28;80(4):1150-1160.

Cell-free translation of GFP protein compared the effects of berkeleylactone A (1) and three known macrolide antibiotics—erythromycin, josamycin, and tylosin—on protein synthesis. J Nat Prod. 2017 Apr 28;80(4):1150-1160.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6147 mL	13.0736 mL	26.1472 mL	52.2944 mL
5mM	0.5229 mL	2.6147 mL	5.2294 mL	10.4589 mL
10mM	0.2615 mL	1.3074 mL	2.6147 mL	5.2294 mL
20mM	0.1307 mL	0.6537 mL	1.3074 mL	2.6147 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.