A-119637 | CAS 255713-47-4

A-119637

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Cat #: V3053 CAS #: 255713-47-4 Purity ≥ 98%

Description: A-119637 is a novel, selective and potent antagonist of the alpha1D adrenoceptor. A-119637 attenuated electrically induced contractions in isolated CC (-logIC(50); 8.12+/-0.15), and relaxed noradrenaline (NA)-contracted preparations by more than 90% at 10(-7) M. The inhibitory effects of A-322312 (10(-7) M) in electrically activated CC were 32.3+/-5.1%, whereas no effect on concentration-response curves for NA was observed in the Acc. A-119637 (0.3 micromol kg(-1), i.p.) tripled the number of erections, and produced a 6 fold increase in the duration of apomorphine-induced erectile responses.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	462.57
Molecular Formula	C25H26N4O3S
CAS No.	255713-47-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Synonyms	A-119637; A 119637; A119637

Related Biological Data

(A) Effects of α-adrenoceptor antagonists or vehicle (10−10 M – 10−6 M; N=7) on contractions induced by electrical field stimulation (18 Hz, 20 V), or (B) by noradrenaline (NA; 3×10−6 M, N=6) in the rat isolated corpus cavernosum. Effects are expressed as per cent enhancement/inhibition/relaxation of contraction, and values are given as mean±standard error of the mean. Br J Pharmacol. 2002 Jul;136(5):701-8.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1618 mL	10.8092 mL	21.6183 mL	43.2367 mL
5mM	0.4324 mL	2.1618 mL	4.3237 mL	8.6473 mL
10mM	0.2162 mL	1.0809 mL	2.1618 mL	4.3237 mL
20mM	0.1081 mL	0.5405 mL	1.0809 mL	2.1618 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.