A-315675 | CAS 335679-69-1

A-315675

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V3089 CAS #: 335679-69-1 Purity ≥ 98%

Description: A-315675, a pyrrolidine-based compound, is a novel and potent anti-infuenza agent. It acts as a neuramidase inhibitor and responds well to resistant strains. A-315675 can inhibit A and B strain influenza virus neuraminidases in enzyme assays and influenza virus replication in cell culture. A-315675 effectively inhibited influenza A N1, N2, and N9 and B strain neuraminidases with inhibitor constant (K(i)) values between 0.024 and 0.31 nM. These values were comparable to or lower than the K(i) values measured for oseltamivir carboxylate (GS4071), zanamivir, and BCX-1812, except for the N1 enzymes that were found to be the most sensitive to BCX-1812.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	326.44
Molecular Formula	C17H30N2O4
CAS No.	335679-69-1
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Synonyms	A315675; A-315675; A 315675

Related Biological Data

Measurement of Ki for the inhibition of B/Memphis/3/89 neuraminidase by A-315675.

Time-dependent inhibition of B/Memphis/3/89 neuraminidase by A-315675. Antimicrob Agents Chemother. 2002 Apr;46(4):1014-21.

Time-dependent inhibition of B/Memphis/3/89 neuraminidase by oseltamivir carboxylate (GS4071).Antimicrob Agents Chemother. 2002 Apr;46(4):1014-21.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0634 mL	15.3168 mL	30.6335 mL	61.2670 mL
5mM	0.6127 mL	3.0634 mL	6.1267 mL	12.2534 mL
10mM	0.3063 mL	1.5317 mL	3.0634 mL	6.1267 mL
20mM	0.1532 mL	0.7658 mL	1.5317 mL	3.0634 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.