A-286501

This product is for research use only, not for human use. We do not sell to patients.

A-286501
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Cat #: V3081 CAS #: 483341-15-7 Purity ≥ 98%

Description: A-286501 is a novel and potent carbocyclic nucleoside AK (Adenosine kinase) inhibitor with an IC50 of 0.47 nM and has analgesic and anti-inflammatory activities. It has no significant activity (IC50 >100 microM) at other sites of ADO (Adenosine) interaction (A1, A2A, A3 receptors, ADO transporter, and ADO deaminase) or other (IC50 value >10 microM) neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter reuptake sites and enzymes, including cyclooxygenases-1 and -2. A-286501 showed equivalent potency in the inhibition of AK from several mammalian species and kinetic studies revealed that A-286501 was a reversible and competitive inhibitor with respect to ADO and non-competitive with respect to MgATP2-

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Molecular Weight (MW)328.17
Molecular FormulaC11H14BrN5O2
CAS No.483341-15-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mM
Water: N/A
Ethanol: N/A
SynonymsA-286501; A 286501; A286501
ProtocolIn VitroIn vitro activity: Kinase Assay: Cell Assay:
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0472 mL15.2360 mL30.4720 mL60.9440 mL
5mM0.6094 mL3.0472 mL6.0944 mL12.1888 mL
10mM0.3047 mL1.5236 mL3.0472 mL6.0944 mL
20mM0.1524 mL0.7618 mL1.5236 mL3.0472 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.