Liquiritigenin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $300 | Check With Us |
| 500mg | $500 | Check With Us |
| 1g | $750 | Check With Us |
: Cat #: V10076 CAS #: 578-86-9 Purity ≥ 99%
Description: Liquiritigenin is a novel and potent flavonoid.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 256.25 |
|---|---|
| Molecular Formula | C15H12O4 |
| CAS No. | 578-86-9 |
| SMILES Code | O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13 |
| Synonyms | Menerba; Liquiritigenin; MF101; MF 101; MF-101 |
| Protocol | In Vitro | Liquiritigenin is dose-response activation of ERE tk-Luc production in U2OS cells transfected with ERβ instead of ERα. Liquiritigenin produces dose-dependent activation of ERβ rather than ERα and time-dependent increases in CECR6, NKG2E, and NKD. The ERβ selectivity of Liquiritigenin is due to the selective recruitment of the co-activator steroid receptor co-activator 2 to the target gene. Liquiritigenin exhibits similar binding affinity for ERα and ERβ and results in SRC-2 selectively recruiting target genes into ERβ cells |
|---|---|---|
| In Vivo | In mouse xenograft models, Liquiritigenin did not stimulate uterine size or tumorigenesis in MCF-7 breast cancer cells |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9024 mL | 19.5122 mL | 39.0244 mL | 78.0488 mL |
| 5mM | 0.7805 mL | 3.9024 mL | 7.8049 mL | 15.6098 mL |
| 10mM | 0.3902 mL | 1.9512 mL | 3.9024 mL | 7.8049 mL |
| 20mM | 0.1951 mL | 0.9756 mL | 1.9512 mL | 3.9024 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.