Equol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $390 | Check With Us |
| 5g | $1053 | Check With Us |
| 10g | $1580 | Check With Us |
: Cat #: V1745 CAS #: 531-95-3 Purity ≥ 98%
Description: Equol [(-)-Equol, (3S)-Equol, (S)-Equol, AUS 131] is an isoflavandiol estrogen metabolized from daidzein, specifically, it is produced by intestinal bacteria in response to soy isoflavone intake in human.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 242.27 |
|---|---|
| Molecular Formula | C15H14O3 |
| CAS No. | 531-95-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 48 mg/mL (198.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 48 mg/mL (198.1 mM) | |
| Synonyms | (-)-(S)-Equol, (-)-Equol, (3S)-Equol, (S)-Equol, AUS 131, Equol, S-Equol, SE 5OH |
| Protocol | In Vitro | (-)-(S)-Equol inhibits the growth of LnCaP, DU145, and PC3 human prostate cancer cell lines. (-)-(S)-Equol induces apoptosis in PC1 cells by downregulating cyclin B1 and CDK21 and upregulating CDK inhibitors (p27 and p3) and upregulating Fas ligands (FasL), resulting in cell cycle arrest in G2/M phase and pro-apoptotic Bim expression. (-)-(S)-Equol increases the expression of FOXO3a, decreases the expression of p-FOXO3a and enhances the nuclear stability of FOXO3a. (-)-(S)-Equol also reduces the expression of MDM2, which is used as E2 ubiquitin ligase for p-FOXO3a, thereby preventing p-FOXO3a degradation by the proteasome |
|---|---|---|
| In Vivo | At day 33, (-)-(S)-Equol inhibited tumor growth by 43.2% and 28.4% compared to controls, indicating no significant toxicity of the compound |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.1276 mL | 20.6381 mL | 41.2763 mL | 82.5525 mL |
| 5mM | 0.8255 mL | 4.1276 mL | 8.2553 mL | 16.5105 mL |
| 10mM | 0.4128 mL | 2.0638 mL | 4.1276 mL | 8.2553 mL |
| 20mM | 0.2064 mL | 1.0319 mL | 2.0638 mL | 4.1276 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.