H3B-5942
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1850 | Check With Us |
| 500mg | $2600 | Check With Us |
| 1g | $3900 | Check With Us |
: Cat #: V31869 CAS #: 2052128-15-9 Purity ≥ 99%
Description: H3B-5942 (H3B5942) is a selective, irreversible (covalent) and orally bioavailable estrogen receptor antagonist with antitumor activity (better than fulvestrant).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 494.63 |
|---|---|
| Molecular Formula | C₃₁H₃₄N₄O₂ |
| CAS No. | 2052128-15-9 |
| SMILES Code | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC/C=C/C(N(C)C)=O)C=C2)C3=CC(C=NN4)=C4C=C3 |
| Synonyms | H3B-5942; H3B 5942; H3B5942 |
| Protocol | In Vitro | H3B-5942 is a selective and irreversible estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERα by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. |
|---|---|---|
| In Vivo | H3B-5942 (1, 3, 10, or 30 mg/kg, p.o, q.d. for 17 days) dose-dependently inhibits tumor growth in MCF7 xenograft model in athymic female nude mice | |
| Animal model | MCF7 xenograft model in athymic female nude mice | |
| Dosages | 1, 3, 10, or 30 mg/kg | |
| Administration | P.O. once a day (q.d.×1) for 17 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0217 mL | 10.1086 mL | 20.2171 mL | 40.4343 mL |
| 5mM | 0.4043 mL | 2.0217 mL | 4.0434 mL | 8.0869 mL |
| 10mM | 0.2022 mL | 1.0109 mL | 2.0217 mL | 4.0434 mL |
| 20mM | 0.1011 mL | 0.5054 mL | 1.0109 mL | 2.0217 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.