TRPM8 antagonist 2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $950 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V31167 CAS #: 259674-19-6 Purity ≥ 99%
Description: TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
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| Molecular Weight (MW) | 398.506 |
|---|---|
| Molecular Formula | C₂₆H₂₆N₂O₂ |
| CAS No. | 259674-19-6 |
| SMILES Code | O=C([C@@H](N(CC1=CC=CC=C1)CC2=CC=CC=C2)CC3=CNC4=CC=CC=C43)OC |
| Protocol | In Vitro | TRPM8 antagonist 2 (Compound 14) is a potent selective TRPM8 antagonist, IC50 0.2 nM for neuropathic pain syndrome research. TRPM8 antagonist 2 in CA2+ Potent inhibition of menthol-induced intracellular CA in fluorescence assays2+ Elevated levels and HEK293 cells stably expressing the rat subtype (IC) of the TRPM8 channel50，40 nM) |
|---|---|---|
| In Vivo | TRPM8 antagonist 2 (1, 10, and 30 mg/kg, subcutaneously) showed significant dose-dependent analgesic activity and inhibited mouse wet-dog shakes (WDS)-like cold hypersensitivity by 30% at 63 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, subcutaneously) reduced Oxaliplatin (OXP)-induced cold dysphonia in mice |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5094 mL | 12.5469 mL | 25.0937 mL | 50.1875 mL |
| 5mM | 0.5019 mL | 2.5094 mL | 5.0187 mL | 10.0375 mL |
| 10mM | 0.2509 mL | 1.2547 mL | 2.5094 mL | 5.0187 mL |
| 20mM | 0.1255 mL | 0.6273 mL | 1.2547 mL | 2.5094 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.