GFB-8438
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $550 | Check With Us |
| 100mg | $950 | Check With Us |
| 200mg | $1425 | Check With Us |
: Cat #: V40197 CAS #: 2304549-73-1 Purity ≥ 99%
Description: GFB-8438 is a novel, highly potent and subtype specific TRPC5 inhibitor with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 386.76 |
|---|---|
| Molecular Formula | C₁₆H₁₄ClF₃N₄O₂ |
| CAS No. | 2304549-73-1 |
| SMILES Code | O=C1CN(C2=C(Cl)C(NN=C2)=O)CCN1CC3=C(C(F)(F)F)C=CC=C3 |
| Protocol | In Vitro | Pretreatment of mouse podocyte with GFB-8438 (1 μM for 30 min), followed by incubation with protamine sulfate, effectively blocked synaptopodin loss and cytoskeletal remodeling |
|---|---|---|
| In Vivo | GFB-8438 (30 mg/kg; s.c.; daily for 3 weeks) is efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of focal segmental glomerulosclerosis (FSGS), significantly reducing both total protein and albumin concentrations in urine | |
| Animal model | Sprague Dawley rats (DOCA-salt rat model of FSGS) | |
| Dosages | 30 mg/kg | |
| Administration | s.c.; daily for 3 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5856 mL | 12.9279 mL | 25.8558 mL | 51.7117 mL |
| 5mM | 0.5171 mL | 2.5856 mL | 5.1712 mL | 10.3423 mL |
| 10mM | 0.2586 mL | 1.2928 mL | 2.5856 mL | 5.1712 mL |
| 20mM | 0.1293 mL | 0.6464 mL | 1.2928 mL | 2.5856 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.