NS6180
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $709 | Check With Us |
| 500mg | $1099 | Check With Us |
| 1g | $1645 | Check With Us |
: Cat #: V2816 CAS #: 353262-04-1 Purity ≥ 98%
Description: NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 323.33 |
|---|---|
| Molecular Formula | C₁₆H₁₂F₃NOS |
| CAS No. | 353262-04-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 47 mg/mLr |
| Water: < 1mg/mLr | |
| Ethanol: < 1mg/mL | |
| Solubility In Vivo | O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3 |
| Synonyms | NS6180; NS-6180; NS 6180. |
| Protocol | In Vitro | NS6180 (0.001-1 μM) shows inhibition of human KCa3.1 with an IC50 value of 9.4 nM and a K50 value of 11 1.7 nM, respectively |
|---|---|---|
| In Vivo | NS6180 (i.v., i.p. and oral administration; 10 mg/kg; twice daily or once daily) has extremely low bioavailability and reduces DNBS-induced experimental colitis in rats | |
| Animal model | Rats | |
| Dosages | 10 mg/kg | |
| Administration | i.v., i.p. and oral administration; 10 mg/kg; twice daily or once daily |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0928 mL | 15.4641 mL | 30.9282 mL | 61.8563 mL |
| 5mM | 0.6186 mL | 3.0928 mL | 6.1856 mL | 12.3713 mL |
| 10mM | 0.3093 mL | 1.5464 mL | 3.0928 mL | 6.1856 mL |
| 20mM | 0.1546 mL | 0.7732 mL | 1.5464 mL | 3.0928 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.