Nifekalant hydrochloride (MS-551)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $400 | To Be Confirmed |
| 250mg | $750 | To Be Confirmed |
| 500mg | $1125 | To Be Confirmed |
: Cat #: V41791 CAS #: 130656-51-8 Purity ≥ 99%
Description: Nifekalant hydrochloride (MS-551) is an IKr potassium channel blocker belonging to the class III antiarrhythmic agent with an IC50 of 10 µM.
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| Molecular Weight (MW) | 441.913 |
|---|---|
| Molecular Formula | C19H28ClN5O5 |
| CAS No. | 130656-51-8 |
| SMILES Code | O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O.[H]Cl |
| Synonyms | MS551; MS-551 |
| Protocol | In Vitro | Nifekalant interacts with the cardiac M2 and the peripheral M3 receptors with a Ki value of 27 and 74 mM, respectively. Nifekalant dose dependently blocks HERG channels with an IC50 value of 7.9 mM, but Nifekalant does not block minK currents in the Xenopus oocyte expression system. Nifekalant blocks HERG channels mainly in their open state in a frequency dependent manner. As a pure K+ channel blocker, Nifekalant does not have negative inotropic effects which amiodarone has via a β-blocking action and does not affect cardiac conduction |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2629 mL | 11.3144 mL | 22.6289 mL | 45.2578 mL |
| 5mM | 0.4526 mL | 2.2629 mL | 4.5258 mL | 9.0516 mL |
| 10mM | 0.2263 mL | 1.1314 mL | 2.2629 mL | 4.5258 mL |
| 20mM | 0.1131 mL | 0.5657 mL | 1.1314 mL | 2.2629 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.