NS3623
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | To Be Confirmed |
| 500mg | $2050 | To Be Confirmed |
| 1g | $3075 | To Be Confirmed |
: Cat #: V26676 CAS #: 343630-41-1 Purity ≥ 99%
Description: NS3623 (NS-3623) is a novel and potent (hERG) and KV4.3 channel activator with antiarrhythmic effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 427.19 |
|---|---|
| Molecular Formula | C15H10BrF3N6O |
| CAS No. | 343630-41-1 |
| Synonyms | NS-3623; NS 3623 |
| Protocol | In Vitro | In isolated canine cardiomyocytes, the application of NS3623 (5 μM) greatly increased the size of the wake, confirming previous studies showing that the drug increased IKr. The effect of NS3623 on cultured cells IKr was also evaluated. After 48 h, the size of the IKr is greatly reduced compared to the newly isolated cells. The peak IKr wake was 0.47±0.08 pA/pF for newly isolated cardiomyocytes and 2.0±28.0 pA/pF for cardiomyocytes cultured for 06 days. The application of NS3623 increases IKr for cultured intermediate cells. Analysis of the current-to-voltage (I-V) relationship of the IKr wake showed that the NS3623 was incubated for 1 and 2 days |
|---|---|---|
| In Vivo | In awake guinea pigs, NS3623 (50 mg/kg) shortened the QT interval by 30±6%. The NS3623 (50 mg/kg) immediately shortens the QTcF interval and significantly reduces it by approximately 30 minutes | |
| Animal model | Anesthetized guinea pig | |
| Dosages | 30 mg/kg | |
| Administration | Intravenous injection; lasting for 3 minutes |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3409 mL | 11.7044 mL | 23.4088 mL | 46.8176 mL |
| 5mM | 0.4682 mL | 2.3409 mL | 4.6818 mL | 9.3635 mL |
| 10mM | 0.2341 mL | 1.1704 mL | 2.3409 mL | 4.6818 mL |
| 20mM | 0.1170 mL | 0.5852 mL | 1.1704 mL | 2.3409 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.