Repaglinide (AG-EE 623ZW)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $150 | Check With Us |
| 2g | $245 | Check With Us |
| 5g | $380 | Check With Us |
: Cat #: V1675 CAS #: 135062-02-1 Purity ≥ 98%
Description: Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm) is a potent and short-acting potassium channel blocker with antidiabetic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 452.59 |
|---|---|
| Molecular Formula | C27H36N2O4 |
| CAS No. | 135062-02-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 91 mg/mL (201.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 91 mg/mL (201.1 mM) | |
| Synonyms | AG-EE-623 ZW; AG-EE-388 ZW; AG-EE623 ZW; AG-EE 388 ZW; AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm |
| Protocol | In Vitro | Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted |
|---|---|---|
| In Vivo | Repaglinide (AG-EE 623ZW) is very rapidly absorbed (tmax less than 1 hour) with a t1/2 of less than one hour. Furthermore, Repaglinide is inactivated in the liver and more than 90 % excreted via the bile. Repaglinide (1 mg/kg p.o.) is effective (P<0.001) as an insulin-releasing agent in a rat model (low-dose streptozotocin) of type 2 diabetes. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2095 mL | 11.0475 mL | 22.0951 mL | 44.1901 mL |
| 5mM | 0.4419 mL | 2.2095 mL | 4.4190 mL | 8.8380 mL |
| 10mM | 0.2210 mL | 1.1048 mL | 2.2095 mL | 4.4190 mL |
| 20mM | 0.1105 mL | 0.5524 mL | 1.1048 mL | 2.2095 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.